New study results show total elimination of HO-MRSA and 98% decrease of MRSA surface burden during trial period Access Study Abstract ActivePure Medical is pleased to announce the publication of Reduction of Methicillin-Resistant Staphylococcus aureus Surface Microbial Burden and related Healthcare Associated Infections with the implementation of an Advanced Photocatalytic Oxidation Technology in a Medical-Surgical Intensive Care Unit. This study highlights the efficacy of ActivePure's novel advanced photocatalytic oxidation (aPCO) technology at reducing microbial burden and healthcare-onset Methicillin-Resistant Staphylococcus aureus (HO-MRSA) infections in a medical-surgical intensive care unit (ICU) despite no change in clinical practice.
The last few years have exposed the risks of infection by spotlighting the issues that already existed, raising their visibility, but also the 21st century solutions that are now available. The results of this study have opened the door for healthcare facilities to protect their areas prone to the spread of healthcare-associated infections, like MRSA, with proven, real-world results.
- Deborah Birx, MD
Chief Medical and Science Advisor, ActivePure Technologies
Methicillin-resistant Staphylococcus aureus (MRSA) is type of the Staphylococcus aureus (staph) bacterium that is resistant to several antibiotics, including methicillin, that are commonly used to treat ordinary staph infections. In healthcare settings-such as U.S. hospitals, where approximately 5% of patients carry MRSA bacteria in their nose or on their skin-MRSA can cause bloodstream infections, pneumonia, or surgical site infections.
Between 2020 and 2021, a statistically significant 14% increase in healthcare-associated infections (HAIs) attributed to MRSA were reported among national acute-care hospitals. The COVID-19 pandemic had not only stymied reduction efforts but also precipitated a rise in invasive healthcare-onset MRSA (HO-MRSA) infections, with increases seen of 12-34% in national MRSA standardized infection ratios in 2020 compared to 2019.
A medical-surgical intensive care unit (ICU) at a suburban hospital had seen similar increases in HO-MRSA infections-defined as a positive culture on or after the 3rd hospital day-despite no change in clinical practice. Between 2021 and 2022, a prospective study of ActivePure's advanced photocatalytic oxidation (aPCO) technology was conducted at the high-acuity facility, including baseline and regular post-activation surface samplings. No changes were made or required to the hospital's cleaning and disinfection practices, trainings, or schedules during this time.
ActivePure's novel aPCO technology resulted in a reduction of microbial burden and HAIs despite no change in clinical practice. The technology reduced MRSA on frequently touched surfaces in a high-traffic ICU, with corresponding decreases in HO-MRSA cases also seen.